Late-stage trial of COVID-19 vaccine paused after patient experiences ‘unexplained illness’


0

Late-stage studies of a possible COVID-19 vaccine are on temporary hold while the company investigates whether a report of a patient with a serious side effect is linked to the shot.

In a statement issued Tuesday evening, AstraZeneca said its “standard review process triggered a pause to vaccination to allow review of safety data.”

AstraZeneca didn’t reveal any information about the possible side effect except to call it “a potentially unexplained illness.” The news site STAT first reported the pause in testing, saying the possible side effect occurred in the United Kingdom.

An AstraZeneca spokesperson confirmed the pause in vaccinations covers studies in the U.S. and other countries. Late last month, AstraZeneca began recruiting 30,000 people in the U.S. for its largest study of the vaccine. It also is testing the vaccine, developed by Oxford University, in thousands of people in Britain, and in smaller studies in Brazil and South Africa.

Two other vaccines are in huge, final-stage tests in the United States, one made by Moderna and the other by Pfizer and Germany’s BioNTech. Those two vaccines work differently than AstraZeneca’s, and the studies already have recruited about two-thirds of the needed volunteers.

AstraZeneca says the pause in vaccinations covers studies in the U.S. and other countries. (Associated Press)

Temporary holds of large medical studies aren’t unusual, and investigating any serious or unexpected reaction is a mandatory part of safety testing. AstraZeneca pointed out that it’s possible the problem could be a coincidence; illnesses of all sorts could arise in studies of thousands of people.

“We are working to expedite the review of the single event to minimize any potential impact on the trial timeline,” the company statement said.

Most important phase of testing

It’s likely the unexplained illness was serious enough to require hospitalization and not a mild side effect such as fever or muscle pain, said Deborah Fuller, a University of Washington researcher who is working on a different COVID-19 vaccine that has not yet started human testing.

“This is not something to be alarmed about,” Fuller said. Instead, it’s reassuring that the company is pausing the study to figure out what’s happening and carefully monitoring the health of study participants.

During the third and final stage of testing, researchers look for any signs of possible side effects that may have gone undetected in earlier patient research. Because of their large size, the studies are considered the most important phase of study for picking less common side effects and establishing safety.

The trials also assess effectiveness by tracking who gets sick and who doesn’t between patients getting the vaccine and those receiving a dummy shot.

The development came the same day that AstraZeneca and eight other drugmakers issued an unusual pledge, vowing to uphold the highest ethical and scientific standards in developing their vaccines.

The announcement follows worries that U.S. President Donald Trump will pressure the U.S. Food and Drug Administration to approve a vaccine before it’s proven to be safe and effective.

The U.S. has invested billions of dollars in efforts to quickly develop multiple vaccines against COVID-19. But public fears that a vaccine is unsafe or ineffective could be disastrous, derailing the effort to vaccinate millions of Americans.

Representatives for the FDA did not immediately respond to requests for comment Tuesday evening.

Story first appeared at CBC.ca

Advertisements

Like it? Share with your friends!

0

What's Your Reaction?

Love It Love It
0
Love It
Hate It Hate It
0
Hate It
Wow Wow
0
Wow
Sad Sad
0
Sad
agree agree
0
agree
disagree disagree
0
disagree
confused confused
0
confused
lol lol
0
lol
omg omg
0
omg

0 Comments

This site uses Akismet to reduce spam. Learn how your comment data is processed.

CBC

Choose A Format
Story
Formatted Text with Embeds and Visuals
Audio
Soundcloud or Mixcloud Embeds
Video
Youtube and Vimeo Embeds
Poll
Voting to make decisions or determine opinions
List
The Classic Internet Listicles
Personality quiz
Series of questions that intends to reveal something about the personality
Trivia quiz
Series of questions with right and wrong answers that intends to check knowledge
Countdown
The Classic Internet Countdowns
Open List
Submit your own item and vote up for the best submission
Ranked List
Upvote or downvote to decide the best list item
Image
Photo or GIF
Meme
Upload your own images to make custom memes